GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs2243480 | 1 | rs56985706 | chr7:65394562 | CCT6P1 | chr7:65216092-65228661:+ | 0.38 | 6 | 3.93E-9 | Diabetic kidney disease |
| THCA | cis | rs2243480 | 1 | rs56985706 | chr7:65394562 | CRCP | chr7:65579805-65619551:+ | -0.26 | -4 | 7.24E-5 | Diabetic kidney disease |
| THCA | cis | rs2243480 | 1 | rs56985706 | chr7:65394562 | RABGEF1 | chr7:66093890-66276446:+ | 0.55 | 6.89 | 1.73E-11 | Diabetic kidney disease |
| THCA | cis | rs17772222 | 1 | rs56987357 | chr14:88824363 | SPATA7 | chr14:88852012-88904802:+ | -0.17 | -3.48 | 0.000542 | Coronary artery calcification |
| THCA | cis | rs515910 | 1 | rs569967 | chr10:105942337 | C10orf79 | chr10:105889647-105992120:- | 0.25 | 8.09 | 4.8E-15 | Attention deficit hyperactivity disorder |
| THCA | cis | rs7714584 | 1 | rs57001853 | chr5:150272452 | LOC134466 | chr5:150310000-150326146:- | 0.39 | 5.41 | 9.98E-8 | Crohn's disease |
| THCA | cis | rs3105593 | 1 | rs57002197 | chr15:50873760 | SPPL2A | chr15:50999739-51057910:- | 0.28 | 7.33 | 9.59E-13 | QT interval |
| THCA | cis | rs12435908 | 1 | rs57012661 | chr14:66172750 | LOC645431 | chr14:65877313-65879335:- | -0.51 | -6.65 | 8.22E-11 | Ischemic stroke |
| THCA | cis | rs17197710 | 1 | rs57012996 | chr11:47194924 | MADD | chr11:47290927-47351582:+ | 0.28 | 3.44 | 0.00063 | Waist-to-hip ratio adjusted for body mass index |
| THCA | cis | rs11190604 | 1 | rs57025426 | chr10:102205868 | SEC31B | chr10:102246403-102289636:- | -0.3 | -10.21 | 2.82E-22 | Palmitoleic acid (16:1n-7) plasma levels |
| THCA | cis | rs2129782 | 1 | rs57040657 | chr8:89414990 | MMP16 | chr8:89049462-89339717:- | 0.32 | 4.96 | 9.78E-7 | Electrodermal activity |
| THCA | cis | rs1027730 | 1 | rs57053582 | chr8:94071156 | C8orf83 | chr8:93895865-94029901:- | 0.27 | 4.43 | 1.19E-5 | Attention deficit hyperactivity disorder |
| THCA | cis | rs2243480 | 1 | rs57057549 | chr7:65405738 | CCT6P1 | chr7:65216092-65228661:+ | 0.41 | 6.45 | 2.67E-10 | Diabetic kidney disease |
| THCA | cis | rs2243480 | 1 | rs57057549 | chr7:65405738 | CRCP | chr7:65579805-65619551:+ | -0.28 | -4.24 | 2.64E-5 | Diabetic kidney disease |
| THCA | cis | rs2243480 | 1 | rs57057549 | chr7:65405738 | RABGEF1 | chr7:66093890-66276446:+ | 0.53 | 6.38 | 4.25E-10 | Diabetic kidney disease |